Apr 24, 2012

SUMMARY of alleged image fraud

Articles of suspicions

Han, C. & Wu, T. J Biol Chem 280, 24053-63 (2005).

Han, C., Michalopoulos, G.K. & Wu, T. J Cell Physiol 207, 261-70 (2006).

Han C, Demetris AJ, Stolz DB, Xu L, Lim K, Wu T. J Biol Chem 281, 24831-46 (2006).

Xu, L., Han, C., Lim, K. & Wu, T. Cancer Res 66, 11859-68 (2006).

Xu, L., Han, C. & Wu, T. J Biol Chem 281, 33982-96 (2006).

Xu, L., Han, C., Lim, K. & Wu, T. J Biol Chem 283, 3077-87 (2008).

Tong Wu, M.D., Ph.D.

Professor and Chair, Department of Pathology and Laboratory Medicine

Tulane University School of Medicine
1430 Tulane Avenue, SL-79, Rm 6519, New Orleans, LA 70112

http://tulane.edu/som/departments/pathology/personnel/faculty/twupage.cfm

http://tulane.edu/som/cancer/tongwu.cfm

Chang Han, M.D., Ph.D.

Associate Professor, Department of Pathology and Laboratory Medicine

Tulane University School of Medicine

TCC Program Member
1430 Tulane Avenue, SL-79, New Orleans, LA 70112

http://tulane.edu/som/departments/pathology/personnel/faculty/chanpath.cfm

http://tulane.edu/som/cancer/changhan.cfm

Biographical Narrative

Dr. Han received her MD from Harbin Medical University, China. She carried out doctoral studies on the detection of human T-cell leukemia virus type-1 in a human T-lyphoblastic lymphoma xenotransplant in nude mouse and an exploration of the mechanism of horizontal oncogenesis in the xenograft, obtaining her Ph.D. She then carried out postdoctoral studies on gene targeting at the Institute of Genetics, Chinese Academy of Sciences, followed by research on the regulation of cytosolic phospholipase A₂alpha (cPLA₂alpha) and cyclooxygenase-2 (COX-2)-derived prostaglandin and related signaling pathways in liver cancer at the Department of Pathology of University of Pittsburgh School of Medicine. She generated two novel transgenic mice with targeted expression of the cPLA₂alpha and COX-2, respectively, in the liver and gained significant expertise in a variety of in vitro and iv vivo model systems for the study of liver cell biology and cancer. In 2005 she was promoted as an assistant professor of pathology. Since relocating to Tulane University in December 2009, she took an Associate Professor position in Pathology and Laboratory Medicine at School of Medicine where she continues her active research in hepatic carcinogenesis.

Apr 23, 2012

Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.

J Biol Chem. 2008 Feb 8;283(6):3077-87. Epub 2007 Nov 20.

Activation of cytosolic phospholipase A2alpha through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2.

Xu L, Han C, Lim K, Wu T.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

• Figure 1A appears to use data also published in Figure 2C from Xu, L., et al.

Cancer Res 66, 11859-68 (2006).

• Figure 9A appears to use data also published in Figure 2B from Xu, L., et al. J

Biol Chem 281, 33982-96 (2006).

A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.

J Biol Chem. 2006 Nov 10;281(45):33982-96. Epub 2006 Sep 11.

A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.

Xu L, Han C, Wu T.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

• Figure 1C and 5B appear to use data also published in Figures 3A from Xu, L., et

al. Cancer Res 66, 11859-68 (2006).

• Figure 3B appears to use data also published in Figures 2A and 2B from Xu, L.,

et al. Cancer Res 66, 11859-68 (2006).

• Figure 2B appears to use data also published in Figure 9A from Xu, L., et al. J

Biol Chem 283, 3077-87 (2008).

• Figure 8E appears to use data also published in Figure 2C from Xu, L., et al.
Cancer Res 66, 11859-68 (2006).

Cross-talk between peroxisome proliferator-activated receptor delta and cytosolicphospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways inhuman hepatocellular carcinoma cells.

Cancer Res. 2006 Dec 15;66(24):11859-68.

Cross-talk between peroxisome proliferator-activated receptor delta and cytosolicphospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways inhuman hepatocellular carcinoma cells.

Xu L, Han C, Lim K, Wu T.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

• Figure 2C appears to use data also published in Figure 1A from Xu, L., et al. J

Biol Chem 283, 3077-87 (2008).

• Figure 3A appears to use data also published in Figure 1C and 5B from Xu, L., et

al. J Biol Chem 281, 33982-96 (2006).

• Figure 2A appears to reuse data from Figure 2B.

• Figure 2A appears to use data also published in Figure 3B from Xu, L., et al. J
Biol Chem 281, 33982-96 (2006).

• Figure 2C appears to use data also published in Figure 8E from Xu, L., et al. J
Biol Chem 281, 33982-96 (2006).

Modulation of Stat3 activation by the cytosolic phospholipase A2alpha andcyclooxygenase-2-controlled prostaglandin E2 signaling pathway.

J Biol Chem. 2006 Aug 25;281(34):24831-46. Epub 2006 Jun 21.

Modulation of Stat3 activation by the cytosolic phospholipase A2alpha andcyclooxygenase-2-controlled prostaglandin E2 signaling pathway.

Han C, Demetris AJ, Stolz DB, Xu L, Lim K, Wu T.

Source

Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. changhan+@pitt.edu

• Figure 6F appears to reuse data presented in Figure 6G

• Figure 9B appears to reuse data also published in Figure 8C from Han, C., et al. J
Biol Chem 28281, 24831-46 (2006).

Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.

J Cell Physiol. 2006 Apr;207(1):261-70.

Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.

Han C, Michalopoulos GK, Wu T.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA.

• Figure 2A appears to use data also published in Figure 3B from Han, C., et al. J

Biol Chem 280, 24053-63 (2005).

• Figure 3 appears to have manipulated the data presented in the Huh7 upper

panel (it appears that the data was cropped out and replaced).

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

J Biol Chem. 2005 Jun 24;280(25):24053-63. Epub 2005 Apr 26.

Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.

Han C, Wu T.

Source

Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.

• Figure 4 appears to reuse data presented in Figure 2D.

• Figure 3B appears to use data also published in Figure 2A from Han, C., et al. J Cell Physiol 207, 261-70 (2006)

• Figure 8C appears to reuse data also published in Figure 9B from Han, C. et al. J
Biol Chem 281, 24831-46 (2006).